- La Bella AA, Andersen MJ, Gervais NC, Molina JJ, Molesan A, Stuckey PV, Wensing L, Nobile CJ, Shapiro RS, Santiago-Tirado FH, Flores-Mireles AL. The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection. Science Advances. 2023 Mar 3; 9(9):eade7689. doi: 10.1126/sciadv.ade7689. PMID: 36867691; PMCID: PMC9984171.
- Andersen MJ, Fong C, La Bella AA, Molina JJ, Molesan A, Champion MM, Howell C, Flores-Mireles AL. Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections. Elife. 2022 Mar 29;11:e75798. doi: 10.7554/eLife.75798. PMID: 35348114; PMCID: PMC8986317.
- Lam LN, Brunson DN, Molina JJ, Flores-Mireles AL, Lemos JA. The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of Enterococcus faecalis virulence. Virulence. 2022 Dec;13(1):592-608. doi: 10.1080/21505594.2022.2056965. PMID: 35341449; PMCID: PMC8966984.
- Kundra S, Lam LN, Kajfasz JK, Casella LG, Andersen MJ, Abranches J, Flores-Mireles AL, Lemos JA. c-di-AMP Is Essential for the Virulence of Enterococcus faecalis. Infect Immun. 2021 Oct 15;89(11):e0036521. doi: 10.1128/IAI.00365-21. Epub 2021 Aug 23. PMID: 34424750; PMCID: PMC8519298.
- Vu HM, Hammers DE, Liang Z, Nguyen GL, Benz ME, Moran TE, Higashi DL, Park CJ, Ayinuola YA, Donahue DL, Flores-Mireles AL, Ploplis VA, Castellino FJ, Lee SW. Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution. Front Cardiovasc Med. 2021 Jun 10;8:667554. doi: 10.3389/fcvm.2021.667554. PMID: 34179133; PMCID: PMC8230121.
- Chambers JM, Addiego A, Flores-Mireles AL, Wingert RA. Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis. Cell Rep. 2020 Nov 10;33(6):108370. doi: 10.1016/j.celrep.2020.108370. PMID: 33176142; PMCID: PMC7731726.
- Gaston JR, Andersen MJ, Johnson AO, Bair KL, Sullivan CM, Guterman LB, White AN, Brauer AL, Learman BS, Flores-Mireles AL, Armbruster CE. Enterococcus faecalis Polymicrobial Interactions Facilitate Biofilm Formation, Antibiotic Recalcitrance, and Persistent Colonization of the Catheterized Urinary Tract. Pathogens. 2020 Oct 13;9(10):835. doi: 10.3390/pathogens9100835. PMID: 33066191; PMCID: PMC7602121.
- Walker JN, Flores-Mireles AL, Lynch AJL, Pinkner C, Caparon MG, Hultgren SJ, Desai A. High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration. World J Urol. 2020 Sep;38(9):2237-2245. doi: 10.1007/s00345-019-03027-8. Epub 2019 Dec 2. PMID: 31792577; PMCID: PMC7778452.
- Russo BT, Ayinuola YA, Singh D, Carothers K, Fischetti VA, Flores-Mireles AL, Lee SW, Ploplis VA, Liang Z, Castellino FJ. The M Protein of Streptococcus pyogenes Strain AP53 Retains Cell Surface Functional Plasminogen Binding after Inactivation of the Sortase A Gene. J Bacteriol. 2020 Apr 27;202(10):e00096-20. doi: 10.1128/JB.00096-20. PMID: 32123038; PMCID: PMC7186463.
- Mursalin MH, Coburn PS, Livingston E, Miller FC, Astley R, Flores-Mireles AL, Callegan MC. Bacillus S-Layer-Mediated Innate Interactions During Endophthalmitis. Front Immunol. 2020 Feb 12;11:215. doi: 10.3389/fimmu.2020.00215. PMID: 32117322; PMCID: PMC7028758.
- Flores-Mireles AL. mSphere of Influence: Uncovering New Ways To Control Multidrug Resistance by Dissecting Essential Cell Processes. mSphere. 2019 Sep 25;4(5):e00648-19. doi: 10.1128/mSphere.00648-19. PMID: 31554727; PMCID: PMC6763773.
- Flores-Mireles A, Hreha TN, Hunstad DA. Pathophysiology, Treatment, and Prevention of Catheter-Associated Urinary Tract Infection. Top Spinal Cord Inj Rehabil. 2019 Summer;25(3):228-240. doi: 10.1310/sci2503-228. PMID: 31548790; PMCID: PMC6743745.
- Di Venanzio G, Flores-Mireles AL, Calix JJ, Haurat MF, Scott NE, Palmer LD, Potter RF, Hibbing ME, Friedman L, Wang B, Dantas G, Skaar EP, Hultgren SJ, Feldman MF. Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes. Nat Commun. 2019 Jun 24;10(1):2763. doi: 10.1038/s41467-019-10706-y. PMID: 31235751; PMCID: PMC6591400.
- Westfall C, Flores-Mireles AL, Robinson JI, Lynch AJL, Hultgren S, Henderson JP, Levin PA. The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance In Vitro and Reduces Antibiotic Efficacy up to 100-Fold In Vivo. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02312-18. doi: 10.1128/AAC.02312-18. PMID: 30782996; PMCID: PMC6496070.
- Colomer-Winter C, Lemos JA, Flores-Mireles AL. Biofilm Assays on Fibrinogen-coated Silicone Catheters and 96-well Polystyrene Plates. Bio Protoc. 2019 Mar 20;9(6):e3196. doi: 10.21769/BioProtoc.3196. PMID: 31106237; PMCID: PMC6519467.
- Colomer-Winter C, Flores-Mireles AL, Baker SP, Frank KL, Lynch AJL, Hultgren SJ, Kitten T, Lemos JA. Manganese acquisition is essential for virulence of Enterococcus faecalis. PLoS Pathog. 2018 Sep 20;14(9):e1007102. doi: 10.1371/journal.ppat.1007102. PMID: 30235334; PMCID: PMC6147510.
- Shen J, Walsh BJC, Flores-Mireles AL, Peng H, Zhang Y, Zhang Y, Trinidad JC, Hultgren SJ, Giedroc DP. Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis. ACS Chem Biol. 2018 Jun 15;13(6):1610-1620. doi: 10.1021/acschembio.8b00230. Epub 2018 May 17. PMID: 29712426; PMCID: PMC6088750.
- Xu, W, Flores-Mireles AL, Cusumano ZT, Takagi E, Hultgren SJ, Caparon MG. 2017. Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection. NPJ Biofilms and Microbiome. 2017 Nov 6;3:28. doi: 10.1038/s41522-017-0036-z.
- Walker JN, Flores-Mireles AL, Pinkner, CL, Schreiber HLt, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ. 2017. Catheterization alters the bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract. PNAS. Published ahead of print September 25, 2017, doi:10.1073/pnas.1707572114
- Flores-Mireles A. L., Walker JN, Potretzke AM, Schreiber HLt, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG. 2016. Antibody-based therapy for enterococcal catheter-associated urinary tract infections. 7(5).
- Flores-Mireles A. L., Walker JN, Bauman TM, Potretzke AM, Schreiber HLt, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A. 2016. Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological J Urol 196:416-421.
- Highlighted in UroToday
- Flores-Mireles, A. L., Pinkner, J. S., Caparon, M. G., and Hultgren, S. J. An EbpA adhesin vaccine prevents catheter-associated UTI by blocking Enterococcus faecalis biofilms formed by exploitation of fibrinogen. Science Translational Medicine.
- Conover, M. S., Flores-Mireles, A. L., Hibbing, M. E. Dodson K, Hultgren SJ. Establishment and Characterization of UTI and CAUTI in a Mouse Model. J Vis Exp: e52892.
- Flores-Mireles A. L., Walker JN, Caparon M, Hultgren SJ. 2015. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol 13:269-284.